While David Lynch's 1980 film The Elephant Man is notable for its prosthetic make-up effects in recreating the deformities of Victorian medical sensation John Merrick (whose name was actually Joseph Merrick, incidentally), the Broadway play of the same name by Bernard Pomerance is equally notable for using no prosthetics whatsoever - relying upon the actor in the title role to convey Merrick's condition.
The role was originated on Broadway by Philip Anglim and then later played by Mark Hamill, Bruce Davison, and - in the clip below - by David Bowie.
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